Replication of a genetic risk score for venous thromboembolism in whites but not in African Americans.

ABSTRACT:

Unlabelled

ESSENTIALS: There is little prospective information on genetic risk scores to predict venous thromboembolism (VT). Community based cohort followed a median of 22.6 years for VT occurrence. A 5-SNP risk score identified whites at risk of VT, but not African Americans. The utility of genetic risk scores for VT is yet to be established.

Background

Case-control studies have created genetic risk scores of single nucleotide polymorphisms (SNPs) associated with venous thromboembolism (VTE) and documented their ability to predict VTE, but prospective data are lacking.

Objective

To test the ability of a genetic risk score to predict VTE incidence in a prospective study, particularly in African Americans.

Methods

We computed a previously proposed genetic risk

SUBMITTER: Folsom AR 

PROVIDER: S-EPMC4715510 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature