Tissue factor-positive tumor microvesicles activate platelets and enhance thrombosis in mice.

ABSTRACT:

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ESSENTIALS: Cancer patients have a high rate of venous thrombosis (VT) but the underlying mechanisms are unknown. Tumor-derived, tissue factor-positive microvesicles in platelet activation in vitro and in vivo were studied. Tumor-derived, tissue factor-positive microvesicles enhanced VT in mice. Platelets may contribute to VT in some cancer patients, and this could be prevented with antiplatelet drugs.

Background

Cancer patients have an approximately 4-fold increased risk of venous thromboembolism (VTE) compared with the general population, and cancer patients with VTE have reduced survival. Tumor cells constitutively release small membrane vesicles called microvesicles (MVs) that may contribute to thrombosis in cancer patients. Clinical studies have shown that le

SUBMITTER: Geddings JE 

PROVIDER: S-EPMC4715578 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature