Latent class instrumental variables: a clinical and biostatistical perspective.

ABSTRACT: In some two-arm randomized trials, some participants receive the treatment assigned to the other arm as a result of technical problems, refusal of a treatment invitation, or a choice of treatment in an encouragement design. In some before-and-after studies, the availability of a new treatment changes from one time period to this next. Under assumptions that are often reasonable, the latent class instrumental variable (IV) method estimates the effect of treatment received in the aforementioned scenarios involving all-or-none compliance and all-or-none availability. Key aspects are four initial latent classes (sometimes called principal strata) based on treatment received if in each randomization group or time period, the exclusion restriction assumption (in which randomization group or time

SUBMITTER: Baker SG 

PROVIDER: S-EPMC4715605 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature