Dual Catalytic Decarboxylative Allylations of α-Amino Acids and Their Divergent Mechanisms.

ABSTRACT: The room temperature radical decarboxylative allylation of N-protected α-amino acids and esters has been accomplished via a combination of palladium and photoredox catalysis to provide homoallylic amines. Mechanistic investigations revealed that the stability of the α-amino radical, which is formed by decarboxylation, dictates the predominant reaction pathway between competing mechanisms.

SUBMITTER: Lang SB 

PROVIDER: S-EPMC4715668 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature