Long-term assessment of esophageal remodeling in patients with pediatric eosinophilic esophagitis treated with topical corticosteroids.

ABSTRACT:

Background

Eosinophilic esophagitis (EoE) is a chronic TH2 inflammatory disease characterized by tissue remodeling that leads to esophageal strictures and food impactions. Effects of therapy on long-term remodeling in patients with pediatric eosinophil-associated diseases have not been previously described.

Objective

We sought to understand the long-term control of esophageal remodeling in patients with EoE.

Methods

We assessed endoscopic and histologic remodeling and TGF-β1 expression in esophageal biopsy specimens from children (n = 32) with EoE treated with topical corticosteroids (TCSs) over 10 years (mean, 4.5 years). We used standardized EoE scoring tools to gauge endoscopic and symptom features.

Results

Seven hundred thirty-eight biopsy specimens from 24

SUBMITTER: Rajan J 

PROVIDER: S-EPMC4715736 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature