Gender-Specific Molecular and Clinical Features Underlie Malignant Pleural Mesothelioma.

ABSTRACT: Malignant pleural mesothelioma (MPM) is an aggressive cancer that occurs more frequently in men, but is associated with longer survival in women. Insight into the survival advantage of female patients may advance the molecular understanding of MPM and identify therapeutic interventions that will improve the prognosis for all MPM patients. In this study, we performed whole-genome sequencing of tumor specimens from 10 MPM patients and matched control samples to identify potential driver mutations underlying MPM. We identified molecular differences associated with gender and histology. Specifically, single-nucleotide variants of BAP1 were observed in 21% of cases, with lower mutation rates observed in sarcomatoid MPM (P < 0.001). Chromosome 22q loss was more frequently associated with the epi

SUBMITTER: De Rienzo A 

PROVIDER: S-EPMC4715909 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature