Noninvasive dissection of mouse sleep using a piezoelectric motion sensor.

ABSTRACT:

Background

Changes in autonomic control cause regular breathing during NREM sleep to fluctuate during REM. Piezoelectric cage-floor sensors have been used to successfully discriminate sleep and wake states in mice based on signal features related to respiration and other movements. This study presents a classifier for noninvasively classifying REM and NREM using a piezoelectric sensor.

New method

Vigilance state was scored manually in 4-s epochs for 24-h EEG/EMG recordings in 20 mice. An unsupervised classifier clustered piezoelectric signal features quantifying movement and respiration into three states: one active; and two inactive with regular and irregular breathing, respectively. These states were hypothesized to correspond to Wake, NREM, and REM, respectively. States p

SUBMITTER: Yaghouby F 

PROVIDER: S-EPMC4715949 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature