Tumor Cell-Derived Periostin Regulates Cytokines That Maintain Breast Cancer Stem Cells.

ABSTRACT:

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Basal-like breast cancer (BLBC) is an aggressive subtype of breast cancer which is often enriched with cancer stem cells (CSC), but the underlying molecular basis for this connection remains elusive. We hypothesized that BLBC cells are able to establish a niche permissive to the maintenance of CSCs and found that tumor cell-derived periostin (POSTN), a component of the extracellular matrix, as well as a corresponding cognate receptor, integrin α(v)β(3), are highly expressed in a subset of BLBC cell lines as well as in CSC-enriched populations. Furthermore, we demonstrated that an intact periostin-integrin β3 signaling axis is required for the maintenance of breast CSCs. POSTN activates the ERK signaling pathway and regulates NF-κB-mediated transcription of key cytokines,

SUBMITTER: Lambert AW 

PROVIDER: S-EPMC4715959 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature