Depressive symptoms, thyroid hormone and autoimmunity in a population-based cohort from Sardinia.

ABSTRACT:

Objective

To evaluate the association between depressive symptoms and thyroid autoimmunity, and the effect of thyroid hormone on the risk of depression.

Methods

We included 3138 individuals from SardiNIA project, none of whom was taking thyroid medication and antidepressants. Thyrotropin (TSH), free thyroxine (FT4), and antibodies against thyroperoxidase (TPOAb) were measured in all the sample. Depressive symptoms were assessed with Center for Epidemiologic Studies Depression Scale (CES-D).

Results

We found no association between TPOAb and depressive symptoms and no linear association between TSH or FT4 levels and depressive symptoms. However, individuals in the lowest and highest FT4 quintiles showed a higher CES-D score compared to individuals in the middle quintile

SUBMITTER: Delitala AP 

PROVIDER: S-EPMC4715961 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature