Model-free Estimation of Recent Genetic Relatedness.

ABSTRACT: Genealogical inference from genetic data is essential for a variety of applications in human genetics. In genome-wide and sequencing association studies, for example, accurate inference on both recent genetic relatedness, such as family structure, and more distant genetic relatedness, such as population structure, is necessary for protection against spurious associations. Distinguishing familial relatedness from population structure with genotype data, however, is difficult because both manifest as genetic similarity through the sharing of alleles. Existing approaches for inference on recent genetic relatedness have limitations in the presence of population structure, where they either (1) make strong and simplifying assumptions about population structure, which are often untenable, or (2)

SUBMITTER: Conomos MP 

PROVIDER: S-EPMC4716688 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature