Effects of testosterone administration on cognitive function in hysterectomized women with low testosterone levels: a dose-response randomized trial.

ABSTRACT:

Purpose

To determine the dose-dependent effects of testosterone administration on cognition in women with low testosterone levels.

Methods

71 hysterectomized women with or without oophorectomy with total testosterone <31 ng/dl and/or free testosterone <3.5 pg/ml received a standardized transdermal estradiol regimen during the 12-week run-in period and were then randomized to receive weekly intramuscular injections of placebo, 3, 6.25, 12.5, or 25 mg testosterone enanthate for 24 weeks. Total testosterone was measured in serum by LC-MS/MS, and free testosterone levels were measured by equilibrium dialysis. Cognitive function was evaluated using a comprehensive battery of standardized neuropsychological tests at baseline and 24 weeks.

Results

46 women who had baseline a

SUBMITTER: Huang G 

PROVIDER: S-EPMC4716804 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature