Expression of bcl-2 gene family during resection induced liver regeneration: comparison between hepatectomized and sham groups.

ABSTRACT: AIM:During liver regeneration cellular proliferation and apoptosis result in tissue remodeling to restore normal hepatic mass and structure. Main regulators of the apoptotic machinery are the Bcl-2 family proteins but their roles are not well defined throughout the liver regeneration. We aimed to analyze the expression levels of bcl-2 gene family members during resection induced liver regeneration. METHODS:We performed semi-quantitative RT-PCR to examine the expression level of bak, bax, bcl-2 and bcl-xL in 70% hepatectomized rat livers during the whole regeneration process and compared to that of the sham and normal groups. RESULTS:The expression of bak and bax was decreased whereas that of bcl-2 and bcl-xL was increased in hepatectomized animals compared to normal liver at most time poin

SUBMITTER: Akcali KC 

PROVIDER: S-EPMC4717020 | biostudies-literature | 2004 Jan

REPOSITORIES: biostudies-literature