Modal variety of microsatellite instability in human endometrial carcinomas.

ABSTRACT:

Purpose

Microsatellite instability (MSI) in human endometrial cancer (EC) was analysed using a unique fluorescent technique. MSI is associated with various human neoplasms. However, the reported frequency of MSI differs widely in each malignancy. Methodological difficulties have in fact been pointed out in its assay techniques.

Methods

We previously established a sensitive fluorescent technique in which the major methodological problems are overcome. Application of this technique has revealed two distinct modes of microsatellite alterations, i.e. Type A and Type B. In the present study, we have applied this technique to 94 ECs.

Results

Significant microsatellite alterations were observed in 38 (40.4%) tumours of the panel. The two modes, Type A and Type B, were indeed

SUBMITTER: Eto T 

PROVIDER: S-EPMC4717170 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature