STK33 promotes hepatocellular carcinoma through binding to c-Myc.

ABSTRACT:

Objective

STK33 has been reported to play an important role in cancer cell proliferation. We investigated the role of STK33 in hepatocellular carcinoma (HCC) and its underlying mechanisms.

Design

251 patients with HCC were analysed for association between STK33 expression and clinical stage and survival rate. Tamoxifen (TAM)-inducible, hepatocyte-specific STK33 transgenic and knockout mice models were used to study the role of STK33 in liver tumorigenesis. HCC cell lines were used to study the role of STK33 in cell proliferation in vitro and in vivo.

Results

STK33 expression was found to be frequently upregulated in patients with HCC. Significant associations were found between increased expression of STK33 and advanced HCC staging and shorter disease-free survival of

SUBMITTER: Yang T 

PROVIDER: S-EPMC4717356 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature