HNF4α is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer.

ABSTRACT:

Background

Worldwide, gastric cancer (GC) is the fourth most common malignancy and the most common cancer in East Asia. Development of targeted therapies for this disease has focused on a few known oncogenes but has had limited effects.

Objective

To determine oncogenic mechanisms and novel therapeutic targets specific for GC by identifying commonly dysregulated genes from the tumours of both Asian-Pacific and Caucasian patients.

Methods

We generated transcriptomic profiles of 22 Caucasian GC tumours and their matched non-cancerous samples and performed an integrative analysis across different GC gene expression datasets. We examined the inhibition of commonly overexpressed oncogenes and their constituent signalling pathways by RNAi and/or pharmacological inhibition.

SUBMITTER: Chang HR 

PROVIDER: S-EPMC4717359 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature