Evidence for treating rheumatoid arthritis to target: results of a systematic literature search update.

ABSTRACT:

Objective

A systematic literature review (SLR; 2009-2014) to compare a target-oriented approach with routine management in the treatment of rheumatoid arthritis (RA) to allow an update of the treat-to-target recommendations.

Methods

Two SLRs focused on clinical trials employing a treatment approach targeting a specific clinical outcome were performed. In addition to testing clinical, functional and/or structural changes as endpoints, comorbidities, cardiovascular risk, work productivity and education as well as patient self-assessment were investigated. The searches covered MEDLINE, EMBASE, Cochrane databases and Clinicaltrial.gov for the period between 2009 and 2012 and separately for the period of 2012 to May of 2014.

Results

Of 8442 citations retrieved in the two S

SUBMITTER: Stoffer MA 

PROVIDER: S-EPMC4717391 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature