Loci associated with N-glycosylation of human IgG are not associated with rheumatoid arthritis: a Mendelian randomisation study.

ABSTRACT:

Objectives

A recent study identified 16 genetic variants associated with N-glycosylation of human IgG. Several of the genomic regions where these single nucleotide polymorphisms (SNPs) reside have also been associated with autoimmune disease (AID) susceptibility, suggesting there may be pleiotropy (genetic sharing) between loci controlling both N-glycosylation and AIDs. We investigated this by testing variants associated with levels of IgG N-glycosylation for association with rheumatoid arthritis (RA) susceptibility using a Mendelian randomisation study, and testing a subset of these variants in a less well-powered study of treatment response and severity.

Methods

SNPs showing association with IgG N-glycosylation were analysed for association with RA susceptibility in 14 361

SUBMITTER: Yarwood A 

PROVIDER: S-EPMC4717396 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature