Synovial tissue volume: a treatment target in knee osteoarthritis (OA).

ABSTRACT:

Background

Synovitis occurring frequently in osteoarthritis (OA) may be a targeted outcome. There are no data examining whether synovitis changes following intra-articular intervention.

Methods

Persons aged 40 years and older with painful knee OA participated in an open label trial of intra-articular steroid therapy. At all time points they completed the Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire. They had a contrast-enhanced (CE) MRI immediately prior to an intra-articular steroid injection with a repeat scan within 20 days. Response status was assessed using the Osteoarthritis Research Society International (OARSI) response criteria. OARSI responders were followed until their pain relapsed either within 20% of baseline or 6 months, shortly after whic

SUBMITTER: O'Neill TW 

PROVIDER: S-EPMC4717397 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature