Pre-trial inter-laboratory analytical validation of the FOCUS4 personalised therapy trial.

ABSTRACT:

Introduction

Molecular characterisation of tumours is increasing personalisation of cancer therapy, tailored to an individual and their cancer. FOCUS4 is a molecularly stratified clinical trial for patients with advanced colorectal cancer. During an initial 16-week period of standard first-line chemotherapy, tumour tissue will undergo several molecular assays, with the results used for cohort allocation, then randomisation. Laboratories in Leeds and Cardiff will perform the molecular testing. The results of a rigorous pre-trial inter-laboratory analytical validation are presented and discussed.

Methods

Wales Cancer Bank supplied FFPE tumour blocks from 97 mCRC patients with consent for use in further research. Both laboratories processed each sample according to an agreed de

SUBMITTER: Richman SD 

PROVIDER: S-EPMC4717430 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature