An activation-repolarization time metric to predict localized regions of high susceptibility to reentry.

ABSTRACT:

Background

Initiation of reentrant ventricular tachycardia (VT) involves complex interactions between front and tail of the activation wave. Recent experimental work has identified the time interval between S2 repolarization proximal to a line of functional block and S2 activation at the adjacent distal side as a critical determinant of reentry.

Objectives

We hypothesized that (1) an algorithm could be developed to generate a spatial map of this interval ("reentry vulnerability index" [RVI]), (2) this would accurately identify a site of reentry without the need to actually induce the arrhythmia, and (3) it would be possible to generate an RVI map in patients during routine clinical procedures.

Methods

An algorithm was developed that calculated RVI between all pairs of

SUBMITTER: Child N 

PROVIDER: S-EPMC4717521 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature