Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson's disease.

ABSTRACT:

Background

Despite decades of intensive research, to date, there is no accepted diagnosis for Parkinson's disease (PD) based on biochemical analysis of blood or CSF. However, neurodegeneration in the brains of PD patients begins several years before the manifestation of the clinical symptoms, pointing to serious flaw/limitations in this approach.

Results

To explore the potential use of alpha-synuclein (α-syn) species as candidate biomarkers for PD, we generated specific antibodies directed against wide array of α-syn species, namely total-, oligomeric- and phosphorylated-Ser129-α-syn (t-, o- and p-S129-α-syn). Next we sought to employ our antibodies to develop highly specific ELISA assays to quantify α-syn species in biological samples. Finally we verified the usefulness of

SUBMITTER: Majbour NK 

PROVIDER: S-EPMC4717559 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature