Microtubule-associated protein 1b is required for shaping the neural tube.

ABSTRACT:

Background

Shaping of the neural tube, the precursor of the brain and spinal cord, involves narrowing and elongation of the neural tissue, concomitantly with other morphogenetic changes that contribue to this process. In zebrafish, medial displacement of neural cells (neural convergence or NC), which drives the infolding and narrowing of the neural ectoderm, is mediated by polarized migration and cell elongation towards the dorsal midline. Failure to undergo proper NC results in severe neural tube defects, yet the molecular underpinnings of this process remain poorly understood.

Results

We investigated here the role of the microtubule (MT) cytoskeleton in mediating NC in zebrafish embryos using the MT destabilizing and hyperstabilizing drugs nocodazole and paclitaxel respect

SUBMITTER: Jayachandran P 

PROVIDER: S-EPMC4717579 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature