The role of primary tumor resection in colorectal cancer patients with asymptomatic, synchronous unresectable metastasis: Study protocol for a randomized controlled trial.

ABSTRACT:

Background

Approximately 20 % of all patients with colorectal cancer are diagnosed as having Stage IV cancer; 80 % of these present with unresectable metastatic lesions. It is controversial whether chemotherapy with or without primary tumor resection (PTR) is effective for the treatment of patients with colorectal cancer with unresectable metastasis. Primary tumor resection could prevent tumor-related complications such as intestinal obstruction, perforation, bleeding, or fistula. Moreover, it may be associated with an increase in overall survival. However, surgery delays the use of systemic chemotherapy and affects the systemic spread of malignancy.

Methods/design

Patients with colon and upper rectal cancer patients with asymptomatic, synchronous, unresectable metastasis wi

SUBMITTER: Kim CW 

PROVIDER: S-EPMC4717596 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature