Multi-omic measurement of mutually exclusive loss-of-function enriches for candidate synthetic lethal gene pairs.

ABSTRACT:

Background

Identification of synthetic lethal interactions in cancer cells could offer promising new therapeutic targets. Large-scale functional genomic screening presents an opportunity to test large numbers of cancer synthetic lethal hypotheses. Methods enriching for candidate synthetic lethal targets in molecularly defined cancer cell lines can steer effective design of screening efforts. Loss of one partner of a synthetic lethal gene pair creates a dependency on the other, thus synthetic lethal gene pairs should never show simultaneous loss-of-function. We have developed a computational approach to mine large multi-omic cancer data sets and identify gene pairs with mutually exclusive loss-of-function. Since loss-of-function may not always be genetic, we look for deleterious mut

SUBMITTER: Wappett M 

PROVIDER: S-EPMC4717622 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature