Influence of Klotho gene polymorphisms on vascular gene expression and its relationship to cardiovascular disease.

ABSTRACT: Klotho protein has been associated with beneficial effects that contribute to the maintenance of cardiovascular health. Diverse studies suggest that alterations in the levels of this molecule may be associated with pathophysiological abnormalities that result in increased cardiovascular risk. The primary aim of this proof-of-concept study was to analyse the existence of a potential link between Klotho gene polymorphisms and the expression level of this gene in the vascular wall, and additionally with the incidence of cardiovascular disease and cardiovascular risk factors. Our results indicate that the variant G-395A, located in the promoter region, influences Klotho gene vascular expression and is associated with the incidence of diabetes. Similarly, the exonic variant KL-VS was associated

SUBMITTER: Donate-Correa J 

PROVIDER: S-EPMC4717853 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature