Antidepressant Response Trajectories and Associated Clinical Prognostic Factors Among Older Adults.

ABSTRACT:

Importance

More than 50% of older adults with late-life major depressive disorder fail to respond to initial treatment with first-line pharmacological therapy.

Objectives

To assess typical patterns of response to an open-label trial of extended-release venlafaxine hydrochloride (venlafaxine XR) for late-life depression and to evaluate which clinical factors are associated with the identified longitudinal response patterns.

Design, setting, and participants

Group-based trajectory modeling was applied to data from a 12-week open-label pharmacological trial conducted in specialty care as part of the Incomplete Response in Late Life: Getting to Remission Study. Clinical prognostic factors, including domain-specific cognitive performance and individual depression symptoms,

SUBMITTER: Smagula SF 

PROVIDER: S-EPMC4718144 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature