Phase II Trial of Nilotinib in Patients With Metastatic Malignant Melanoma Harboring KIT Gene Aberration: A Multicenter Trial of Korean Cancer Study Group (UN10-06).

ABSTRACT:

Background

KIT has been suggested to be a potential therapeutic target for malignant melanoma. We evaluated the antitumor activity and safety of the KIT inhibitor nilotinib in metastatic melanoma patients harboring KIT gene mutations or amplifications.

Methods

We conducted a phase II multicenter trial of nilotinib in metastatic malignant melanoma with KIT mutations or amplifications. Patients received 400 mg oral nilotinib twice daily. The primary endpoint was response rate, and if seven or more responders were observed from the cumulative 36 patients, nilotinib would be considered worthy of further testing in this study population.

Results

Between October 2009 and June 2013, 176 patients underwent molecular screening for KIT gene aberrations, and 42 patients harborin

SUBMITTER: Lee SJ 

PROVIDER: S-EPMC4718426 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature