Antibacterial properties of the CFTR potentiator ivacaftor.

ABSTRACT:

Background

Ivacaftor increases CFTR channel activity and improves pulmonary function for individuals bearing a G551D mutation. Because ivacaftor structurally resembles quinolone antibiotics, we tested the hypothesis that ivacaftor possesses antibacterial properties.

Methods

Bioluminescence, colony forming unit, and minimal inhibitory concentration assays were used to assess viability of Staphylococcus aureus, Pseudomonas aeruginosa and multiple clinical microbial isolates.

Results

Ivacaftor induced a dose-dependent reduction in bioluminescence of S. aureus and decreased the number of colony forming units. We observed a similar but less robust effect in P. aeruginosa following outer membrane permeabilization. Ivacaftor inhibited the growth of respiratory isolates of S.

SUBMITTER: Reznikov LR 

PROVIDER: S-EPMC4718582 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature