Nanotechnology as a New Therapeutic Approach to Prevent the HIV-Infection of Treg Cells.

ABSTRACT:

Background

HIV-1 has proved to infect regulatory T cells (Treg) modifying their phenotype and impairing their suppressive capacity. As Treg cells are a crucial component in the preservation of the immune homeostasis, we researched that the antiviral capacity of carboxilan dendrimers prevents the HIV-1 infection of Treg and their effects. The phenotype and suppressive capacity of Treg treated or non-treated with carbosilane dendrimers were studied by flow cytometry. Treated and non-treated Treg from healthy donors were infected with HIV-1NL4.3. The infection of Treg cells by HIV-1, and protective effect of two dendrimers were determined by measuring antigen p24gag in the supernatant of the culture and intracellular.

Results

The Treg cells were treated with cationic and anioni

SUBMITTER: Jaramillo-Ruiz D 

PROVIDER: S-EPMC4718685 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature