The Innate Immune Receptor PGRP-LC Controls Presynaptic Homeostatic Plasticity.

ABSTRACT: It is now appreciated that the brain is immunologically active. Highly conserved innate immune signaling responds to pathogen invasion and injury and promotes structural refinement of neural circuitry. However, it remains generally unknown whether innate immune signaling has a function during the day-to-day regulation of neural function in the absence of pathogens and irrespective of cellular damage or developmental change. Here we show that an innate immune receptor, a member of the peptidoglycan pattern recognition receptor family (PGRP-LC), is required for the induction and sustained expression of homeostatic synaptic plasticity. This receptor functions presynaptically, controlling the homeostatic modulation of the readily releasable pool of synaptic vesicles following inhibition of pos

SUBMITTER: Harris N 

PROVIDER: S-EPMC4718712 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature