Bromodomain and extraterminal (BET) proteins regulate biliary-driven liver regeneration.

ABSTRACT:

Background & aims

During liver regeneration, hepatocytes are derived from pre-existing hepatocytes. However, if hepatocyte proliferation is compromised, biliary epithelial cells (BECs) become the source of new hepatocytes. We recently reported on a zebrafish liver regeneration model in which BECs extensively contribute to hepatocytes. Using this model, we performed a targeted chemical screen to identify important factors that regulate BEC-driven liver regeneration, the mechanisms of which remain largely unknown.

Methods

Using Tg(fabp10a:CFP-NTR) zebrafish, we examined the effects of 44 selected compounds on BEC-driven liver regeneration. Liver size was assessed by fabp10a:DsRed expression; liver marker expression was analyzed by immunostaining, in situ hybridization and quan

SUBMITTER: Ko S 

PROVIDER: S-EPMC4718879 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature