Seroprevalence of Enterovirus 71 Antibody Among Children in China: A Systematic Review and Meta-analysis.

ABSTRACT:

Background

Hand, foot and mouth disease mostly affects children and carries a substantial disease burden in the Western Pacific region. Enterovirus 71 (EV71) is the most virulent causative agent, and a monovalent vaccine against EV71 will soon become commercially available in China. An improved understanding of EV71 epidemiology would aid policy decisions regarding childhood immunization in China. We aimed to assess and summarize information to date from individual seroepidemiologic studies of EV71 in mainland China to determine patterns of the age-specific risk of infection.

Methods

A systematic review and meta-analysis of studies of children aged 0-15 years, published in English or Chinese, was conducted. Estimates of seroprevalence were summarized by age group. A mixed-ef

SUBMITTER: Yang B 

PROVIDER: S-EPMC4718881 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature