Disrupted sensorimotor and social-cognitive networks underlie symptoms in childhood-onset schizophrenia.

ABSTRACT: Schizophrenia is increasingly recognized as a neurodevelopmental disorder with altered connectivity among brain networks. In the current study we examined large-scale network interactions in childhood-onset schizophrenia, a severe form of the disease with salient genetic and neurobiological abnormalities. Using a data-driven analysis of resting-state functional magnetic resonance imaging fluctuations, we characterized data from 19 patients with schizophrenia and 26 typically developing controls, group matched for age, sex, handedness, and magnitude of head motion during scanning. This approach identified 26 regions with decreased functional correlations in schizophrenia compared to controls. These regions were found to organize into two function-related networks, the first with regions ass

SUBMITTER: Berman RA 

PROVIDER: S-EPMC4719706 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature