Early changes in blood-based joint tissue destruction biomarkers are predictive of response to tocilizumab in the LITHE study.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is characterized by gradual joint destruction. Tocilizumab (TCZ) significantly suppresses symptoms, however not all patients are protected from joint damage. We investigated whether early measurement of specific biomarkers could predict early joint protection response to tocilizumab.

Method

Serum biomarkers (CRPM, VICM, C1M, C2M, C3M (MMP-degraded CRP, vimentin type I, II and III collagen), CTX-I/OC (bone turnover), and CRP) were measured in 740 RA patients (the LITHE study) treated with Placebo, or 4 or 8 mg/kg TCZ. Early responders were those with ≥20 % improvement in SJC or TJC by week 16. The biomarkers' predictability of response was investigated by AUROC and classification regression tree analysis.

Results

The best biomarker

SUBMITTER: Bay-Jensen AC 

PROVIDER: S-EPMC4719735 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature