Evolutionary and Functional Relationships in the Truncated Hemoglobin Family.

ABSTRACT: Predicting function from sequence is an important goal in current biological research, and although, broad functional assignment is possible when a protein is assigned to a family, predicting functional specificity with accuracy is not straightforward. If function is provided by key structural properties and the relevant properties can be computed using the sequence as the starting point, it should in principle be possible to predict function in detail. The truncated hemoglobin family presents an interesting benchmark study due to their ubiquity, sequence diversity in the context of a conserved fold and the number of characterized members. Their functions are tightly related to O2 affinity and reactivity, as determined by the association and dissociation rate constants, both of which can b

SUBMITTER: Bustamante JP 

PROVIDER: S-EPMC4720485 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature