Immunotherapies for Immune-Mediated Myopathies: A Current Perspective.

ABSTRACT: Until recently, the treatment of immune-mediated inflammatory myopathies has largely been empirical with glucocorticoids, steroid-sparing immunosuppressive drugs, and intravenous immunoglobulin. However, a proportion of patients are only partially responsive to these therapies, and there has been a need to consider alternative treatment approaches. In particular, patients with inclusion body myositis are resistant to conventional immunotherapies or show only a transient response, and remain a major challenge. With increasing recognition of the different subtypes of immune-mediated inflammatory myopathies, and improved understanding of their pathogenesis, more targeted treatments are now being trialled. The overall approach to treatment, and novel therapies targeting B cells, T cells, and s

SUBMITTER: Needham M 

PROVIDER: S-EPMC4720681 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature