Ontology highlight
ABSTRACT:
SUBMITTER: Rankin LC
PROVIDER: S-EPMC4720992 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Nature immunology 20151130 2
Intestinal T cells and group 3 innate lymphoid cells (ILC3 cells) control the composition of the microbiota and gut immune responses. Within the gut, ILC3 subsets coexist that either express or lack the natural cytoxicity receptor (NCR) NKp46. We identified here the transcriptional signature associated with the transcription factor T-bet-dependent differentiation of NCR(-) ILC3 cells into NCR(+) ILC3 cells. Contrary to the prevailing view, we found by conditional deletion of the key ILC3 genes S ...[more]