Correlation of the lung microbiota with metabolic profiles in bronchoalveolar lavage fluid in HIV infection.

ABSTRACT:

Background

While 16S ribosomal RNA (rRNA) sequencing has been used to characterize the lung's bacterial microbiota in human immunodeficiency virus (HIV)-infected individuals, taxonomic studies provide limited information on bacterial function and impact on the host. Metabolic profiles can provide functional information on host-microbe interactions in the lungs. We investigated the relationship between the respiratory microbiota and metabolic profiles in the bronchoalveolar lavage fluid of HIV-infected and HIV-uninfected outpatients.

Results

Targeted sequencing of the 16S rRNA gene was used to analyze the bacterial community structure and liquid chromatography-high-resolution mass spectrometry was used to detect features in bronchoalveolar lavage fluid. Global integration of

SUBMITTER: Cribbs SK 

PROVIDER: S-EPMC4721204 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature