Frailty and Mortality Outcomes in Cognitively Normal Older People: Sex Differences in a Population-Based Study.

ABSTRACT:

Objectives

To characterize frailty in cognitively normal older adults at baseline and to investigate the relationship between frailty and mortality.

Design

Population-based prospective cohort study: Mayo Clinic Study of Aging.

Setting

Olmsted County, Minnesota.

Participants

Cognitively normal older persons aged 70 and older (mean age 78.8±5.2, 50.2% male; N=2,356).

Measurements

Frailty was assessed at baseline using a 36-item Frailty Index. Four frailty subgroups were identified based on the Frailty Index (≤0.10 (fit), 0.11-0.20 (at risk), 0.21-0.30 (frail), >0.30 (frailest)). All participants underwent comprehensive clinical and cognitive assessments. The association between frailty and mortality was assessed using Cox proportional hazards models.

Re

SUBMITTER: Bartley MM 

PROVIDER: S-EPMC4721254 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature