Cost-effectiveness of retreatment with varenicline after failure with or relapse after initial treatment for smoking cessation.

ABSTRACT:

Objectives

A recent trial showed the clinical benefit of retreatment with varenicline in subjects failing on the initial treatment, or relapsing after initial success. The objective of this study was to evaluate the cost-effectiveness of retreatment with varenicline compared with other smoking cessation interventions.

Methods

A published Markov model was adapted to compare one quit attempt of varenicline followed by retreatment to treatment/retreatment with nicotine replacement therapy (NRT), bupropion or placebo, and with only 1 quit attempt of varenicline. Efficacy was obtained from clinical trials. Incidence of smoking-related diseases was based on published data. Cost of therapies and complications was obtained from databases and literature.

Results

For 1000 smoke

SUBMITTER: Annemans L 

PROVIDER: S-EPMC4721453 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature