In vivo contaminant partitioning to silicone implants: Implications for use in biomonitoring and body burden.

ABSTRACT: Silicone polymers are used for a wide array of applications from passive samplers in environmental studies, to implants used in human augmentation and reconstruction. If silicone sequesters toxicants throughout implantation, it may represent a history of exposure and potentially reduce the body burden of toxicants influencing the risk of adverse health outcomes such as breast cancer. Objectives of this research included identifying a wide variety of toxicants in human silicone implants, and measuring the in vivo absorption of contaminants into silicone and surrounding tissue in an animal model. In the first study, eight human breast implants were analyzed for over 1400 organic contaminants including consumer products, chemicals in commerce, and pesticides. A total of 14 compounds including

SUBMITTER: O'Connell SG 

PROVIDER: S-EPMC4721514 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature