Respiratory Viral Detection in Children and Adults: Comparing Asymptomatic Controls and Patients With Community-Acquired Pneumonia.

ABSTRACT:

Background

The clinical significance of viruses detected in patients with community-acquired pneumonia (CAP) is often unclear.

Methods

We conducted a prospective study to identify the prevalence of 13 viruses in the upper respiratory tract of patients with CAP and concurrently enrolled asymptomatic controls with real-time reverse-transcriptase polymerase chain reaction. We compared age-stratified prevalence of each virus between patients with CAP and controls and used multivariable logistic regression to calculate attributable fractions (AFs).

Results

We enrolled 1024 patients with CAP and 759 controls. Detections of influenza, respiratory syncytial virus, and human metapneumovirus were substantially more common in patients with CAP of all ages than in controls (AFs n

SUBMITTER: Self WH 

PROVIDER: S-EPMC4721902 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature