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HIV Disrupts Human T Cells That Target Mycobacterial Glycolipids.

ABSTRACT: Single-cell analysis captures the heterogeneity of T-cell populations that target defined antigens. Human immunodeficiency virus (HIV) infection results in defects of antimycobacterial immunity, which remain poorly defined. We therefore recruited a small number of subjects, including those with latent and active M. tuberculosis infection, with or without concomitant HIV infection, and tracked the mycobacterial glycolipid-reactive T-cell repertoire by using CD1b tetramers. Glycolipid-reactive T cells expressed memory markers and the HIV coreceptors CD4 and CCR5; they were not detected in subjects with HIV-associated active M. tuberculosis infection. HIV infection may affect T cells that recognize mycobacterial glycolipids and influence immunity.

SUBMITTER: Kasprowicz VO

PROVIDER: S-EPMC4721911 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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HIV Disrupts Human T Cells That Target Mycobacterial Glycolipids.

Kasprowicz Victoria O VO Cheng Tan-Yun TY Ndung'u Thumbi T Sunpath Henry H Moody D Branch DB Kasmar Anne G AG

The Journal of infectious diseases 20150915 4

Single-cell analysis captures the heterogeneity of T-cell populations that target defined antigens. Human immunodeficiency virus (HIV) infection results in defects of antimycobacterial immunity, which remain poorly defined. We therefore recruited a small number of subjects, including those with latent and active M. tuberculosis infection, with or without concomitant HIV infection, and tracked the mycobacterial glycolipid-reactive T-cell repertoire by using CD1b tetramers. Glycolipid-reactive T c ...[more]

PMID: 26374910

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