Parent-mediated intervention versus no intervention for infants at high risk of autism: a parallel, single-blind, randomised trial.

ABSTRACT:

Background

Risk markers for later autism identified in the first year of life present plausible intervention targets during early development. We aimed to assess the effect of a parent-mediated intervention for infants at high risk of autism on these markers.

Methods

We did a two-site, two-arm assessor-blinded randomised controlled trial of families with an infant at familial high risk of autism aged 7-10 months, testing the adapted Video Interaction to Promote Positive Parenting (iBASIS-VIPP) versus no intervention. Families were randomly assigned to intervention or no intervention groups using a permuted block approach stratified by centre. Assessors, but not families or therapists, were masked to group assignment. The primary outcome was infant attentiveness to parent. Re

SUBMITTER: Green J 

PROVIDER: S-EPMC4722333 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature