Gene expression profiling in necrotizing enterocolitis reveals pathways common to those reported in Crohn's disease.

ABSTRACT:

Background

Necrotizing enterocolitis (NEC) is the most frequent life-threatening gastrointestinal disease experienced by premature infants in neonatal intensive care units. The challenge for neonatologists is to detect early clinical manifestations of NEC. One strategy would be to identify specific markers that could be used as early diagnostic tools to identify preterm infants most at risk of developing NEC or in the event of a diagnostic dilemma of suspected disease. As a first step in this direction, we sought to determine the specific gene expression profile of NEC.

Methods

Deep sequencing (RNA-Seq) was used to establish the gene expression profiles in ileal samples obtained from preterm infants diagnosed with NEC and non-NEC conditions. Data were analyzed with Ingenuity

SUBMITTER: Tremblay E 

PROVIDER: S-EPMC4722613 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature