Analysis of TMEFF2 allografts and transgenic mouse models reveals roles in prostate regeneration and cancer.

ABSTRACT:

Background

Previous results from our lab indicate a tumor suppressor role for the transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) in prostate cancer (PCa). Here, we further characterize this role and uncover new functions for TMEFF2 in cancer and adult prostate regeneration.

Methods

The role of TMEFF2 was examined in PCa cells using Matrigel(TM) cultures and allograft models of PCa cells. In addition, we developed a transgenic mouse model that expresses TMEFF2 from a prostate specific promoter. Anatomical, histological, and metabolic characterizations of the transgenic mouse prostate were conducted. The effect of TMEFF2 in prostate regeneration was studied by analyzing branching morphogenesis in the TMEFF2-expressing mouse lobes and a

SUBMITTER: Corbin JM 

PROVIDER: S-EPMC4722803 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature