Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia.

ABSTRACT:

Background

Chronic lymphocytic leukemia (CLL) primarily affects older persons who often have coexisting conditions in addition to disease-related immunosuppression and myelosuppression. We conducted an international, open-label, randomized phase 3 trial to compare two oral agents, ibrutinib and chlorambucil, in previously untreated older patients with CLL or small lymphocytic lymphoma.

Methods

We randomly assigned 269 previously untreated patients who were 65 years of age or older and had CLL or small lymphocytic lymphoma to receive ibrutinib or chlorambucil. The primary end point was progression-free survival as assessed by an independent review committee.

Results

The median age of the patients was 73 years. During a median follow-up period of 18.4 months, ibrutinib

SUBMITTER: Burger JA 

PROVIDER: S-EPMC4722809 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature