Prognostic Significance of Biomarkers in Pulmonary Arterial Hypertension.

ABSTRACT:

Rationale

Pulmonary arterial hypertension (PAH) is a rare progressive disease of the pulmonary vasculature that is characterized by endothelial dysfunction, inflammation, and right ventricular dysfunction.

Objectives

The main objective was to determine whether endothelial, inflammatory, and cardiac biomarkers would be associated with the World Health Organization functional assessment and survival in patients with PAH.

Methods

We performed a retrospective cohort study of patients with PAH enrolled in the Randomized Clinical Trial of Aspirin and Simvastatin for Pulmonary Arterial Hypertension (ASA-STAT). Biomarkers (N-terminal fragment of pro-BNP [NT-pro-BNP], von Willebrand factor [vWF], soluble P selectin, C-reactive protein, total and high-density lipoprotein choles

SUBMITTER: Al-Naamani N 

PROVIDER: S-EPMC4722842 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature