Dynamic shifts in brain network activation during supracapacity working memory task performance.

ABSTRACT: Despite significant advances in understanding how brain networks support working memory (WM) and cognitive control, relatively little is known about how these networks respond when cognitive capabilities are overtaxed. We used a fine-grained manipulation of memory load within a single trial to exceed WM capacity during functional magnetic resonance imaging to investigate how these networks respond to support task performance when WM capacity is exceeded. Analyzing correct trials only, we observed a nonmonotonic (inverted-U) response to WM load throughout the classic WM network (including bilateral dorsolateral prefrontal cortex, posterior parietal cortex, and presupplementary motor areas) that peaked later in individuals with greater WM capacity. We also observed a relative increase in act

SUBMITTER: Van Snellenberg JX 

PROVIDER: S-EPMC4722876 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature