Breast implant-associated anaplastic large cell lymphoma: two distinct clinicopathological variants with different outcomes.

ABSTRACT:

Background

ALK-negative anaplastic large cell lymphoma associated with breast implant (i-ALCL) has been recently recognized as a distinct entity. Among 43 830 lymphomas registered in the French Lymphopath network since 2010, 300 breast lymphomas comprising 25 peripheral T-cell lymphomas (PTCL) were reviewed. Among PTCL, ALK-negative ALCL was the most frequent and all of them were associated with breast implants.

Patients and methods

Since 2010, all i-ALCL cases were collected from different institutions through Lymphopath. Immuno-morphologic features, molecular data and clinical outcome of 19 i-ALCLs have been retrospectively analyzed.

Results

The median age of the patients was 61 years and the median length between breast implant and i-ALCL was 9 years. Most implants

SUBMITTER: Laurent C 

PROVIDER: S-EPMC4722894 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature